Reacción #62325

Ecuación de reacción

tri-p-tolylphosphine

3-vinyl-4-methoxy-1-trityl-1H-indazole-5-carbonitrile

3-bromopyridine

→

title compound

4-Methoxy-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carbonitrile

Disolventes

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONThe reaction solution was added with silica gel
2. 2
   Otrothe solvent was evaporated
3. 3
   Otrothe resultant residue was purified by column chromatography (hexane:ethyl acetate=7:3)

Procedimiento

300 mg of 3-vinyl-4-methoxy-1-trityl-1H-indazole-5-carbonitrile and 180 μl of 3-bromopyridine were dissolved in a mixed solvent of 1 mL triethylamine/5 mL acetonitrile, added with 40 mg of tri-p-tolylphosphine and 27 mg of palladium acetate (II), and heated at 110° C. for 24 hours. The reaction solution was added with silica gel, the solvent was evaporated, and the resultant residue was purified by column chromatography (hexane:ethyl acetate=7:3), to afford 120 mg of the title compound as a pale yellow oil.

Fuente