Reacción #62281

Ecuación de reacción

sodium hydrogen carbonate

3-naphthalen-2-yl-1-trityl-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile

trifluoroacetic acid

→

title compound

Rendimiento 94.8%

3-(Naphthalen-2-yl)-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile

Rendimiento 94.8%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate
2. 2
   Lavadowashed with water
3. 3
   Secadodried over magnesium sulfate
4. 4
   OtroAfter evaporating
5. 5
   Otrothe residue was purified
6. 6
   Otroseparated by silica gel column chromatography (ethyl acetate:n-hexane=3:1)

Procedimiento

To 10 mL of a solution containing 360 mg of 3-naphthalen-2-yl-1-trityl-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile obtained by Production example 15 in dichloromethane, 3 mL of trifluoroacetic acid was added at room temperature and stirred for 2 hours. The reaction solution was added with aqueous sodium hydrogen carbonate, extracted with ethyl acetate, washed with water, and dried over magnesium sulfate. After evaporating, the residue was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=3:1), to afford 180 mg of the title compound as a colorless powder.

Fuente