Reacción #62144

Ecuación de reacción

4-(2-Quinolin-2-yl-ethyl)-benzoic acid

acetonitrile

O,N-Dimethyl-hydroxylamine hydrogen chloride

sodium hydroxide

→

title compound

Rendimiento 88.0%

N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide

Rendimiento 88.0%

Disolventes

dioxane

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with chloroform, dried magnesium sulfate
2. 2
   Filtraciónfiltered
3. 3
   Concentraciónconcentrated
4. 4
   LavadoBiotage MPLC chromatography eluting with 20-50% ethyl acetate

Procedimiento

To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid (530 mg) in dioxane 5 ml/acetonitrile 5 ml was added triethylamine (0.60 ml) and O,N-Dimethyl-hydroxylamine hydrogen chloride (240 mg). After 72 h, the reaction mixture was poured into 1N sodium hydroxide solution and extracted with chloroform, dried magnesium sulfate, filtered and concentrated. Biotage MPLC chromatography eluting with 20-50% ethyl acetate provided the title compound (516 mg, 88%). MS: (M+H m/z=321.1).

Fuente