Reacción #621030

Ecuación de reacción

1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

3-bromopropyl 4-fluorophenyl ether

→

desired product

Rendimiento 43.7%

1-{3-[(4-fluorophenyl)oxy]propyl}-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide

Rendimiento 43.7%

Disolventes

CH3CN

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowere reacted

Procedimiento

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0182 g, 0.0621 mmol) and 3-bromopropyl 4-fluorophenyl ether (0.0173 g, 0.0742 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0143 g, 43.7%). EI-MS m/z 446(M+) Rt (1.96 min).

Fuente