Reacción #62044

Ecuación de reacción

HCl

4-Isothiocyanato-benzoic acid t-butyl ester

4-isothiocyanato-benzoic acid t-butyl ester

KOH

cyanoacetamide

→

4-(2-Carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester

Rendimiento 83.5%

4-(2-carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester

Rendimiento 83.5%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe precipitate obtained
2. 2
   Filtraciónwas filtered
3. 3
   Lavadowashed with water
4. 4
   Otrodried under vacuum

Procedimiento

4-Isothiocyanato-benzoic acid t-butyl ester 2 (28.3 gm, 120.4 mmol) was taken into DMF (200 ml). To this KOH (6.74 gm, 120.4 mmol) and cyanoacetamide (10.21 gm, 120.4 mmol) were added. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was acidified with 1N HCl, the precipitate obtained was filtered, washed with water, and dried under vacuum, to provide 32.10 gm of 4-(2-Carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester 3.

Fuente