Reacción #61975

Ecuación de reacción

sodium bicarbonate

4-hydroxybenzaldehyde

piperidine

sodium triacetoxyborohydride

→

title compound

4-Piperidin-1-ylmethyl-phenol

Disolventes

DCE

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with DCM (5×100 mL)
2. 2
   SecadoThe combined organic phases were dried (magnesium sulfate)
3. 3
   Otroevaporated

Procedimiento

A solution of 4-hydroxybenzaldehyde (10 g), piperidine (8.9 mL), and acetic acid (4.7 mL) in DCE (200 mL) was treated with sodium triacetoxyborohydride (24 g). After 16 h, the resulting mixture was treated with saturated aqueous sodium bicarbonate (100 mL) and extracted with DCM (5×100 mL). The combined organic phases were dried (magnesium sulfate) and evaporated. Trituration of the residue with ethyl acetate gave the title compound as a white crystalline solid (5.5 g).

Fuente