Reacción #61972

Ecuación de reacción

4-hydroxybenzaldehyde

1-bromo-3-chloropropane

potassium carbonate

→

title compound

4-(3-Chloro-propoxy)-benzaldehyde

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturato reflux for 16 h
3. 3
   FiltraciónThe resulting mixture was filtered
4. 4
   Otrothe filtrate was evaporated
5. 5
   workup.DISTILLATIONDistillation of the residue (0.5 mm Hg, 220° C.)

Procedimiento

A suspension of 4-hydroxybenzaldehyde (40 g), 1-bromo-3-chloropropane (63 mL), and potassium carbonate (136 g) in acetone (920 mL) was heated to reflux for 16 h. The resulting mixture was filtered, and the filtrate was evaporated. Distillation of the residue (0.5 mm Hg, 220° C.) gave the title compound as a pale yellow oil that crystallized on standing (46 g).

Fuente