Reacción #619645

Ecuación de reacción

Thieno[3,2-d]pyrimidin-4(3H)-one

bromine

→

title compound

7-bromo-3H-thieno[3,2-d]pyrimidin-4-one

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was cooled to room temperature
2. 2
   workup.DISTILLATIONdistilled under reduced pressure
3. 3
   Otroto remove acetic acid
4. 4
   Otrothe solid thus obtained
5. 5
   Filtraciónwas filtered
6. 6
   Lavadowashed with ether
7. 7
   Otrodried

Procedimiento

Thieno[3,2-d]pyrimidin-4(3H)-one (12.5 g) was dissolved in acetic acid (52 mL), and bromine (13 mL) was added thereto. The reaction mixture was stirred at 120° C. for 12 hours in a hermetically sealed reactor. The reaction mixture was cooled to room temperature and distilled under reduced pressure to remove acetic acid. The reaction mixture was placed in ice water, and the solid thus obtained was filtered and washed with ether, and dried to obtain the title compound (7.8 g).

Fuente