Reacción #619193

ord-c1f153f4163341ecb427d2c242e8264d

Ecuación de reacción

CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester
CCOC(=O)CSc1cnc(NC(=O)N(C2CCCCCC2)C2CCC2)s1
[2-(3-Cycloheptyl-3-cyclobutyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester
C1CCCC(NC2CCC2)CC1
cycloheptyl-cyclobutylamine
→
O=C(O)CSc1cnc(NC(=O)N(C2CCCCCC2)C2CCC2)s1
title compound
O=C(O)CSc1cnc(NC(=O)N(C2CCCCCC2)C2CCC2)s1
[2-(3-Cyclobutyl-3-cycloheptyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid

Reactantes

CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester
CCOC(=O)CSc1cnc(NC(=O)N(C2CCCCCC2)C2CCC2)s1
[2-(3-Cycloheptyl-3-cyclobutyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester
—
( B )
C1CCCC(NC2CCC2)CC1
cycloheptyl-cyclobutylamine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroHydrolysis

Procedimiento

[2-(3-Cycloheptyl-3-cyclobutyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester prepared as described in general procedures (A) and (B) using cycloheptyl-cyclobutylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: USRE045183E1uspto-grants-2014_10