Reacción #619152

Ecuación de reacción

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester

→

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto degas the mixture
2. 2
   Otro(24 h)
3. 3
   FiltraciónAfter filtering
4. 4
   Concentraciónconcentration
5. 5
   Otrothe pure acid was obtained by trituration

Procedimiento

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester (30 mg, 0.057 mmol) was combined with palladium on carbon (20 mg) in MeOH. Vacuum was applied to degas the mixture. The reaction was subjected to hydrogen and vigorous stirring until no ester could be detected (24 h). After filtering and concentration, the pure acid was obtained by trituration.

Fuente