Reacción #619117

Ecuación de reacción

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

→

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester

Rendimiento 47.7%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe content was degassed
2. 2
   FiltraciónThe mixture was filtered through celite
3. 3
   Concentraciónthe filtrate was concentrated
4. 4
   OtroThe residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1

Procedimiento

To a solution of 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester (Example 257) (75 mg, 0.18 mmol) in methanol was added Pd/C (150 mg). The content was degassed and was placed under hydrogen atmosphere for 12 h. The mixture was filtered through celite, and the filtrate was concentrated. The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1 to give 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester (35 mg) in 47% yield.

Fuente