Reacción #619102

ord-4015e90da0d7413d83a34d7a044f167e

Ecuación de reacción

CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-Bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CCOC(=O)c1c[nH]c(S)n1
ethyl-2-mercapto-1H-imidazole-4-carboxylate
→
CCOC(=O)c1c[nH]c(Sc2cnc(NC(=O)N(C3CCCC3)C3CCC(C)CC3)s2)n1
2-{2-[3-Cyclopentyl-3-(4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-1H-imidazole-4-carboxylic acid ethyl ester

Reactantes

CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCC2)CC1
3-(5-Bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea
CCOC(=O)c1c[nH]c(S)n1
ethyl-2-mercapto-1H-imidazole-4-carboxylate

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPrepared

Procedimiento

Prepared as described in general procedure (E) using 3-(5-bromo-thiazol-2-yl)-1-cyclopentyl-1-(4-methyl-cyclohexyl)-urea (Example 202) and ethyl-2-mercapto-1H-imidazole-4-carboxylate.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: USRE045183E1uspto-grants-2014_10