Reacción #619099

ord-c393464220414c19bb4be6acf9e1f27e

Ecuación de reacción

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCSCC1
3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea
O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCSCC1
3-(5-Bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea
COC(=O)CCS
3-mercaptopropionic acid methyl ester
→
COC(=O)CCSc1cnc(NC(=O)N(C2CCCCC2)C2CCSCC2)s1
3-{2-[3-Cyclohexyl-3-(tetrahydro-thiopyran-4-yl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid methyl ester

Reactantes

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCSCC1
3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea
O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCSCC1
3-(5-Bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea
COC(=O)CCS
3-mercaptopropionic acid methyl ester

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPrepared

Procedimiento

Prepared as described in general procedure (D) using 3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea (Example 190) and 3-mercaptopropionic acid methyl ester.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: USRE045183E1uspto-grants-2014_10