Reacción #619087

Ecuación de reacción

water

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea

NCS

→

3-(5-Chloro-thiazol-2-yl)-1-cyclohexyl-1-piperidin-1-yl-urea

Disolventes

DCM

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   SecadoThe organic phase was dried (MgSO4)
3. 3
   Otrothe solvent was removed in vacuo
4. 4
   workup.ADDITIONMeCN (1 mL) was added whereupon the product
5. 5
   Otroprecipitated
6. 6
   FiltraciónThe product was filtered off
7. 7
   Otrodried

Procedimiento

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea (50 mg, 0.16 mmol), prepared in an identical manner to Example 94 was dissolved in DCM (1 mL) and NCS (26 mg, 0.19 mmol)) was added. The reaction mixture was stirred for 3 days before DCM (20 mL) and water (20 mL) was added. The organic phase was dried (MgSO4) and the solvent was removed in vacuo. MeCN (1 mL) was added whereupon the product precipitated. The product was filtered off and dried. Yield: 20 mg.

Fuente