Reacción #619083

Ecuación de reacción

Dicyclohexylamine

aminothiazole

carbonyldiimidazole

→

title product

1,1-Dicyclohexyl-3-thiazol 2 yl urea

Disolventes

ethyl acetate

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe reaction stirred overnight at room temperature
2. 2
   Lavadowashed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL)
3. 3
   Secadodried over magnesium sulphate
4. 4
   Concentraciónconcentrated in vacuo
5. 5
   Otrothe residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min)

Procedimiento

To a solution of aminothiazole (50 mg, 0.5 mmol) in dichloromethane was added carbonyldiimidazole (81 mg, 0.5 mmol) and the solution stirred 2 h at room temperature. Dicyclohexylamine (1 eq) was then added and the reaction stirred overnight at room temperature. The reaction mixture is then diluted with ethyl acetate (8 mL), washed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL), dried over magnesium sulphate, concentrated in vacuo, and the residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min) to give the title product (52 mg).

Fuente