Reacción #61878

Ecuación de reacción

compound

N-[5-(N-tert-butoxycarbonylsulfamoylamino)-4,6-dimethyl-1-octylindolin-7-yl]-2,2-dimethylpropanamide

hydrogen chloride 2-propanol

Diethyl ether

→

title compound

N-(4,6-dimethyl-1-octyl-5-sulfamoylaminoindolin-7-yl)-2,2-dimethylpropanamide hydrochloride

Disolventes

formic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooling
2. 2
   Filtraciónthe precipitated crystals were collected by filtration

Procedimiento

The compound (1.86 g) obtained in Example 5 was dissolved in formic acid (7.5 mL) and 8.51 M hydrogen chloride—2-propanol solution (1.98 mL) was added under ice-cooling. The mixture was stirred at the same temperature for 20 min. Diethyl ether (50 mL) was added, and the precipitated crystals were collected by filtration to give the title compound as crystals (1.34 g).

Fuente