Reacción #61845

Ecuación de reacción

1-benzo[b]thiophen-4-yl-ethanone

4-bromobenzo[b]thiophene

1-vinyloxy-butane

→

1-benzo[b]thiophen-4-yl-2-bromo-ethanone

Condiciones de reacción

Procedimiento

1-benzo[b]thiophen-4-yl-2-bromo-ethanone was synthesised from 1-benzo[b]thiophen-4-yl-ethanone (available by the palladium coupling of 4-bromobenzo[b]thiophene with 1-vinyloxy-butane) according to the method in Example 10A(a) (6.8 g, 92%) as an orange oil; 1H NMR (CDCl3): 4.6 (2H, s), 7.4 (1H, t, J=7.8 Hz), 7.65 (1H, d, J=5.7 Hz), 7.95 (1H, dd, J=7.8, 0.9 Hz), 8.1 (1H, dt, J=7.8, 0.9 Hz), 8.3 (1H, dd, J=5.7, 0.9 Hz).

Fuente