Reacción #61728

Ecuación de reacción

1-(4-chlorophenyl)ethane-1-one

N,N Dimethylformamide diisopropylacetal

→

title compound

Rendimiento 99.0%

(2E)-3-Dimethylamino-1-(4-chlorophenyl)prop-2-en-1-one

Rendimiento 99.0%

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux for 16 hours
2. 2
   FiltraciónThe resulting solid was collected via filtration
3. 3
   Lavadowashed with hexanes

Procedimiento

A solution of 1-(4-chlorophenyl)ethane-1-one (35.0 g, 226 mmol) and N,N Dimethylformamide diisopropylacetal (35 mL) was heated to reflux for 16 hours. The reaction mixture was cooled to room temperature and treated with hexanes (50 mL). The resulting solid was collected via filtration and washed with hexanes to provide the title compound as a yellow solid (47.12 g, 99% yield): HPLC Retention Time; 6.45 min (Method B). M+1; 209.

Fuente