Reacción #61670

Ecuación de reacción

sodium hydride

5-methoxy-1-methyl-1,3-dihydro-benzimidazol-2-one

DMF

1-iodo-4-methyl-4-nitro-pentane

DMF

→

5-methoxy-3-methyl-1-(3-methyl-3-nitro-butyl)-1,3-dihydro-benzimidazol-2-one

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate
2. 2
   LavadoThe combined organic phases are washed with water
3. 3
   Otrodried
4. 4
   Otroevaporated down
5. 5
   workup.STIRRINGThe solid remaining is stirred with diethyl ether

Procedimiento

1.1 g (28 mmol) 60% sodium hydride are added to 2.5 g (14 mmol) 5-methoxy-1-methyl-1,3-dihydro-benzimidazol-2-one in 30 mL DMF while being cooled with the ice bath. After 30 minutes a solution of 1-iodo-4-methyl-4-nitro-pentane in 20 mL DMF is piped in and the mixture is stirred overnight. It is diluted with water and extracted with ethyl acetate. The combined organic phases are washed with water, dried and evaporated down. The solid remaining is stirred with diethyl ether.

Fuente