Reacción #61669

Ecuación de reacción

methylamine

3-fluoro-4-nitro-anisol

potassium carbonate

water

→

(5-methoxy-2-nitro-phenyl)-methyl-amine

Disolventes

THF

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe organic phase is washed successively with water and ammonium chloride solution
2. 2
   Otrodried
3. 3
   Otroevaporated down
4. 4
   workup.STIRRINGThe yellow solid remaining is stirred with hexane

Procedimiento

83.5 mL (167.0 mmol) of a 2 molar solution of methylamine in THF are added dropwise to 14.3 g (83.56 mmol) 3-fluoro-4-nitro-anisol and 12.71 g (92.02 mmol) potassium carbonate in 200 mL dichloromethane. The mixture is stirred overnight and then combined with water. The organic phase is washed successively with water and ammonium chloride solution, dried and evaporated down. The yellow solid remaining is stirred with hexane. Yield: 12.7 g (84%); mass spectroscopy: [M+H]+=183.

Fuente