Reacción #61645

Ecuación de reacción

tert-butyl [3-methyl-3-(6-methyl-2-oxo-2,3-dihydro-benzimidazol-1-yl)-butyl]-carbamate

hydrochloric acid

→

1-(3-amino-1,1-dimethyl-propyl)-6-methyl-1,3-dihydro-benzimidazol-2-one

Disolventes

dioxane

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling to ambient temperature the solvent
2. 2
   workup.DISTILLATIONis distilled off

Procedimiento

A solution of 1.50 g (4.5 mmol) tert-butyl [3-methyl-3-(6-methyl-2-oxo-2,3-dihydro-benzimidazol-1-yl)-butyl]-carbamate in 100 mL dioxane is combined with 10 mL 4 molar hydrochloric acid in dioxane and then heated to 90° C. for 90 minutes, during which time a white precipitate settles out. After cooling to ambient temperature the solvent is distilled off and the residue is stirred in diethyl ether. White solid. Yield: 1.04 g (86%; hydrochloride); mass spectroscopy: [M+H]+=234.

Fuente