Reacción #615865

Ecuación de reacción

2-bromoisonicotinic acid

potassium carbonate

phenylboronic acid

→

2-phenylisonicotinic acid

Disolventes

DME

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe resulting reaction mixture
2. 2
   Temperaturacooled to rt
3. 3
   FiltraciónAfter filtration over celite the reaction mixture
4. 4
   Filtraciónthe white precipitate was filtered off
5. 5
   Lavadowashed with water

Procedimiento

2-bromoisonicotinic acid (0.210 g, 1.040 mmol) was dissolved in degassed DME (Volume: 8 ml) under nitrogen. Tetrakis(triphenylphosphine)palladium(0) (0.060 g, 0.052 mmol) was added, the resulting reaction mixture was stirred for 15 min. Then aqueous potassium carbonate (4.16 ml, 8.32 mmol) and phenylboronic acid (0.171 g, 1.403 mmol) were added subsequently. The resulting RM was refluxed at 95° C. for 18 h and then cooled to rt. After filtration over celite the reaction mixture was acidified to pH 3-4 and the white precipitate was filtered off and washed with water

Fuente