Reacción #61555

Ecuación de reacción

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-4-(2,2,2-trifluoro-ethoxy)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

HCl

→

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]4-(2,2,2-trifluoro-ethoxy)-1H-pyrazole-3,5-dicarboxylic acid 3-ethyl ester

Disolventes

THF

NaOH

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe precipitating product was collected by filtration
2. 2
   Otrodried under reduced pressure

Procedimiento

To a solution of 400 mg 1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-4-(2,2,2-trifluoro-ethoxy)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester in 5 ml THF and 0.9 ml 1N NaOH were added. After standing for 16 h, the solution was acidified using 1 N HCl to pH 1. The precipitating product was collected by filtration and dried under reduced pressure. Yield: 142 mg.

Fuente