Reacción #61540

Ecuación de reacción

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-ethyl ester

→

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-hydroxymethyl-2H-pyrazole-3-carboxylic acid

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroquenched with diluted HCl
2. 2
   Filtraciónfiltered through a chem elut® cartridge by elution with ethyl acetate and DCM
3. 3
   ConcentraciónAfter concentration under reduced pressure the crude residue
4. 4
   Otrowas directly subjected to the next reaction step

Procedimiento

To a solution of 1 g 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-ethyl ester in 15 ml THF 314 mg LiBH4 were added cautiously. Then the reaction mixture was stirred for 16 h, quenched with diluted HCl and filtered through a chem elut® cartridge by elution with ethyl acetate and DCM. After concentration under reduced pressure the crude residue was directly subjected to the next reaction step. Yield: 800 mg.

Fuente