Reacción #61525

Ecuación de reacción

hydrochloric acid

1-furan-2-yl-ethanone

oxalic acid diethyl ester

KOt-Bu

→

4-Furan-2-yl-2,4-dioxo-butyric acid ethyl ester

Disolventes

THF

ethyl acetate

water

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic layer was separated
2. 2
   Lavadowashed with 150 ml water
3. 3
   Secadodried over MgSO4
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated under reduced pressure
6. 6
   Otroto yield a white solid

Procedimiento

To a solution of 16 g oxalic acid diethyl ester in 350 ml THF, 10.1 g KOt-Bu were added at 0° C. Then 10 g 1-furan-2-yl-ethanone in 50 ml THF were added dropwise. After 1 h the reaction mixture was diluted with 300 ml ethyl acetate and 200 mnl water. This solution was acidified with diluted hydrochloric acid to pH 5. The organic layer was separated, washed with 150 ml water, dried over MgSO4, filtered and concentrated under reduced pressure to yield a white solid.

Fuente