Reacción #61521

Ecuación de reacción

HCl

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester

NaOH

→

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-methyl ester

Disolventes

water THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with DCM (3×50 ml)
2. 2
   SecadoThe organic phase was dried over MgSO4
3. 3
   Filtraciónfiltered
4. 4
   Otrothe solvent removed under reduced pressure
5. 5
   OtroThe residue was subjected to the next reaction step without further purification

Procedimiento

To a solution of 1.7 g 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester in 10 ml water/THF 1:1, 4 ml of a 1M aqueous NaOH were added at RT and the mixture was stirred for 3 h with LCMS reaction control. Then the reaction mixture was acidified to pH 3 with half concentrated HCl and extracted with DCM (3×50 ml). The organic phase was dried over MgSO4, filtered and the solvent removed under reduced pressure. The residue was subjected to the next reaction step without further purification.

Fuente