Reacción #61511

Ecuación de reacción

5-Thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester

NaH

3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole

water

→

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónwas filtered through a chem elut® cartridge by elution with ethyl acetate
2. 2
   Concentraciónconcentrated under reduced pressure
3. 3
   OtroThe residue was directly subjected to the subsequent saponification reaction without further purification

Procedimiento

To a solution of 2.0 g 5-Thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester in 5 ml DMF, 360 mg NaH (60% in mineral oil) and subsequently 2.8 g 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole [prepared by adopting a procedure described by Ewing, William R.; Becker, Michael R.; Choi-Sledeski, Yong Mi; Pauls, Heinz W.; He, Wei; Condon, Stephen M.; Davis, Roderick S.; Hanney, Barbara A.; Spada, Alfred P.; Burns, Christopher J.; Jiang, John Z.; Li, Aiwen; Myers, Michael R.; Lau, Wan F.; Poli, Gregory B; PCT Int. Appl. (2001) 460 pp. WO 0107436 A2] were added and the mixture was stirred at 80° C. for 1 h. After the addition of 5 ml water the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate and then concentrated under reduced pressure. The residue was directly subjected to the subsequent saponification reaction without further purification. Yield: 4 g.

Fuente