Reacción #61483

Ecuación de reacción

3-Trifluoracetyl-7-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine

formic acid

→

3-trifluoracetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carbaldehyde

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool
2. 2
   Filtraciónfiltered
3. 3
   Extracciónthe filtrate extracted with ethyl acetate
4. 4
   LavadoThe combined organic layers were washed with saturated sodium bicarbonate solution
5. 5
   Otrodried
6. 6
   Otroevaporated

Procedimiento

3-Trifluoracetyl-7-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine (20.3 g) and nickel-aluminium alloy (35.5 g) in 75% aq. formic acid (400 ml) were heated at 80° C. for 3 h. The reaction was allowed to cool, filtered and the filtrate extracted with ethyl acetate. The combined organic layers were washed with saturated sodium bicarbonate solution, dried and evaporated to give 3-trifluoracetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carbaldehyde (20.0 g) as a yellow oil.

Fuente