Reacción #61469

Ecuación de reacción

6-chloro-2-piperazin-1-yl-quinoline hydrochloride

2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid

ethyl acetate

→

title compound

[4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-cyclopropylmethoxy-5-methanesulfonyl -phenyl)-methanone

Disolventes

acetonitrile

Condiciones de reacción

Procedimiento

Prepared in analogy to example 1.1 b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride (Example 1.20b) and 2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid (Example 2.6) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid. MS (m/e): 500.3 (M+H+; 100%)

Fuente