Reacción #61468

ord-93387aadda324c1a93279990476aedca

Ecuación de reacción

Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-chloro-2-piperazin-1-yl-quinoline hydrochloride
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)O)C(F)(F)F
5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid
CCOC(C)=O
ethyl acetate
→
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1)C(F)(F)F
title compound
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1)C(F)(F)F
[4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone

Reactantes

Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-chloro-2-piperazin-1-yl-quinoline hydrochloride
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)O)C(F)(F)F
5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid
CCOC(C)=O
ethyl acetate

Reactivos

Ninguno

Disolventes

CC#N
acetonitrile

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared in analogy to example 1.1 b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride (Example 1.20b) and 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (Example 2.7) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07429585B2uspto-grants-2008_09