Reacción #61466

ord-f1f815d04fe1462cb6da0710fb7b2689

Ecuación de reacción

Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-chloro-2-piperazin-1-yl-quinoline hydrochloride
CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)O
2-diethylamino-5-methanesulfonyl-benzoic acid
CCOC(C)=O
ethyl acetate
→
CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
title compound
CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
[4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-diethylamino-5-methanesulfonyl -phenyl)-methanone

Reactantes

Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-chloro-2-piperazin-1-yl-quinoline hydrochloride
CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)O
2-diethylamino-5-methanesulfonyl-benzoic acid
CCOC(C)=O
ethyl acetate

Reactivos

Ninguno

Disolventes

CC#N
acetonitrile

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared in analogy to example 1.1 b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride (Example 1.20b) and 2-diethylamino-5-methanesulfonyl-benzoic acid (Example 2.5) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid. MS (m/e): 501.4 (M+H+; 100%)

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07429585B2uspto-grants-2008_09