Reacción #61455

ord-a7e2a650119a4800b1a9042da623b375

Ecuación de reacción

Cl.c1ccc2nc(N3CCNCC3)cnc2c1
2-piperazin-1-yl-quinoxaline hydrochloride
CS(=O)(=O)c1ccc(OC2CCCC2)c(C(=O)O)c1
2-cyclopentyloxy-5-methanesulfonyl-benzoic acid
CCOC(C)=O
ethyl acetate
→
CS(=O)(=O)c1ccc(OC2CCCC2)c(C(=O)N2CCN(c3cnc4ccccc4n3)CC2)c1
title compound
CS(=O)(=O)c1ccc(OC2CCCC2)c(C(=O)N2CCN(c3cnc4ccccc4n3)CC2)c1
(2-Cyclopentyloxy-5-methanesulfonyl-phenyl)-(4-quinoxalin-2-yl-piperazin-1-yl)-methanone

Reactantes

Cl.c1ccc2nc(N3CCNCC3)cnc2c1
2-piperazin-1-yl-quinoxaline hydrochloride
CS(=O)(=O)c1ccc(OC2CCCC2)c(C(=O)O)c1
2-cyclopentyloxy-5-methanesulfonyl-benzoic acid
CCOC(C)=O
ethyl acetate

Reactivos

Ninguno

Disolventes

CC#N
acetonitrile

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared in analogy to example 1.1(b) from 2-piperazin-1-yl-quinoxaline hydrochloride and 2-cyclopentyloxy-5-methanesulfonyl-benzoic acid (example 2.3) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a yellowish foam.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07429585B2uspto-grants-2008_09