Reacción #61447

ord-e0438a7b174843c8a39e6fdf9ab17a95

Ecuación de reacción

Clc1ccc2nc(Cl)ccc2c1
2,6-dichloroquinoline
CC(C)(C)OC(=O)N1CCNCC1
piperazine-1-carboxylic acid tert-butyl ester
→
CC(C)(C)OC(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
title compound
CC(C)(C)OC(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
4-(6-Chloro-quinolin-2-yl)-piperazine-1-carboxylic Acid Tert.-butyl Ester

Reactantes

Clc1ccc2nc(Cl)ccc2c1
2,6-dichloroquinoline
CC(C)(C)OC(=O)N1CCNCC1
piperazine-1-carboxylic acid tert-butyl ester

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroCrystallisation from methanol

Procedimiento

Prepared in analogy to example 1.18(a) from 2,6-dichloroquinoline and piperazine-1-carboxylic acid tert-butyl ester. Crystallisation from methanol yields the title compound as a colorless solid.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07429585B2uspto-grants-2008_09