Reacción #61445

ord-cc255be60ca9459dbc4d48a836655a38

Ecuación de reacción

Cl.c1ccc2nc(N3CCNCC3)ccc2c1
2-piperazin-1-yl-quinoline hydrochloride
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isopropoxy-5-methanesulfonyl-benzoic acid
→
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3ccccc3n2)CC1
title compound
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3ccccc3n2)CC1
(2-Isopropoxy-5-methanesulfonyl-phenyl)-(4-quinolin-2-yl-piperazin-1-yl)-methanone

Reactantes

Cl.c1ccc2nc(N3CCNCC3)ccc2c1
2-piperazin-1-yl-quinoline hydrochloride
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isopropoxy-5-methanesulfonyl-benzoic acid

Reactivos

Ninguno

Disolventes

CC#N
acetonitrile
CCOCC
diethyl ether

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared in analogy to example 1.1(b) from 2-piperazin-1-yl-quinoline hydrochloride and 2-isopropoxy-5-methanesulfonyl-benzoic acid (example 2.2) in acetonitrile. Trituration in diethyl ether yields the title compound as a yellowish foam.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07429585B2uspto-grants-2008_09