Reacción #61441

ord-c276ef5c8d6e4cc3acfe87ddaeb40ba1

Ecuación de reacción

Cc1nc2cc(N3CCNCC3)ccc2s1.Cl
2-methyl-5-piperazin-1-yl-benzothiazole hydrochloride
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isopropoxy-5-methanesulfonyl-benzoic acid
→
Cc1nc2cc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OC(C)C)CC3)ccc2s1
title compound
Cc1nc2cc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OC(C)C)CC3)ccc2s1
(2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(2-methyl-benzothiazol-5-yl)-piperazin-1-yl]-methanone

Reactantes

Cc1nc2cc(N3CCNCC3)ccc2s1.Cl
2-methyl-5-piperazin-1-yl-benzothiazole hydrochloride
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isopropoxy-5-methanesulfonyl-benzoic acid

Reactivos

Ninguno

Disolventes

CC#N
acetonitrile
CCOCC
diethyl ether

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared in analogy to example 1.1(b) from 2-methyl-5-piperazin-1-yl-benzothiazole hydrochloride and 2-isopropoxy-5-methanesulfonyl-benzoic acid (example 2.2) in acetonitrile. Trituration in diethyl ether yields the title compound as a yellowish solid.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07429585B2uspto-grants-2008_09