Reacción #61426

ord-5503c30ef5834086b2673b6c0316c85a

Ecuación de reacción

CS(=O)(=O)c1ccc(OC2CCCC2)c(C(=O)O)c1
2-cyclopentyloxy-5-methanesulfonyl-benzoic acid
CCS(=O)(=O)c1ccc2oc(N3CCNCC3)nc2c1.Cl
5-ethanesulfonyl-2-piperazin-1-yl-benzoxazole hydrochloride
→
CCS(=O)(=O)c1ccc2oc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OC4CCCC4)CC3)nc2c1
title compound
CCS(=O)(=O)c1ccc2oc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OC4CCCC4)CC3)nc2c1
(2-Cyclopentyloxy-5-methanesulfonyl-phenyl)-[4-(5-ethanesulfonyl-benzoxazol-2-yl)-piperazin-1-yl]-methanone

Reactantes

CS(=O)(=O)c1ccc(OC2CCCC2)c(C(=O)O)c1
2-cyclopentyloxy-5-methanesulfonyl-benzoic acid
CCS(=O)(=O)c1ccc2oc(N3CCNCC3)nc2c1.Cl
5-ethanesulfonyl-2-piperazin-1-yl-benzoxazole hydrochloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe crude material was purified by chromatography (SiO2, ethyl acetate)

Procedimiento

Prepared in analogy to example 1.1 b) from 2-cyclopentyloxy-5-methanesulfonyl-benzoic acid (Example 2.3) and 5-ethanesulfonyl-2-piperazin-1-yl-benzoxazole hydrochloride. The crude material was purified by chromatography (SiO2, ethyl acetate) to yield the title compound as a colorless solid.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07429585B2uspto-grants-2008_09