Reacción #61381

Ecuación de reacción

methanol

3-cyano-1-n-propanol

triethylamine

trityl chloride

→

desired product

Rendimiento 61.7%

4-(Trityloxy)butanenitrile

Rendimiento 61.7%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGstirred for 1 h
2. 2
   ConcentraciónAfter concentration
3. 3
   Otrothe residue was purified on a column of silica gel

Procedimiento

To a solution of 3-cyano-1-n-propanol (16.85 g, 198 mmol, prepared by method of Blicke, et al., J. Org. Chem. 1961, 26, 3685) in dichloromethane (250 mL) were added triethylamine (80.1 g, 792 mmol) and trityl chloride (82.8 g, 297 mmol) at room temperature and the mixture was stirred for 16 h. To the reaction mixture was added methanol (25 mL) and stirred for 1 h. After concentration, the residue was purified on a column of silica gel using ethyl acetate and hexanes as eluent to give 40 g (61.7%) of the desired product.

Fuente