Reacción #611739

Ecuación de reacción

hex-5-ynoic acid

EDC.HCl

bis(2-methoxyethyl)amine

→

title compound

N,N-bis(2-Methoxyethyl)hex-5-ynamide

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowas then washed with hydrochloric acid (1 M, 2×500 mL) and water (500 mL)
2. 2
   OtroThe organic layer was dried
3. 3
   Otroevaporated in vacuo

Procedimiento

To a solution of hex-5-ynoic acid (7.11 g, 63.4 mmol), EDC.HCl (14.0 g, 72.9 mmol) and DMAP (387 mg, 3.17 mmol) in DCM (600 mL) at 0° C. was added bis(2-methoxyethyl)amine (9.3 mL, 63 mmol). The resulting mixture was warmed to RT for 20 hr and was then washed with hydrochloric acid (1 M, 2×500 mL) and water (500 mL). The organic layer was dried and evaporated in vacuo to afford the title compound, Intermediate B, as a yellow oil (16 g, 97%): 1H NMR (400 MHz, CDCl3) δ: 1.88 (3H, m), 2.26 (2H, m), 2.49 (2H, m), 3.32 (6H, s), 3.51 (4H, m), 3.55 (4H, m)

Fuente