Reacción #61078

Ecuación de reacción

6-bromo-2-pyridinamine

1-chloro-2-isocyanatoethane

→

title compound

Rendimiento 66.0%

N-(6-Bromo-2-pyridinyl)-N′-(2-chloroethyl)urea

Rendimiento 66.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe crude mixture was partitioned between CH2Cl2 and water
2. 2
   OtroThe phases were separated
3. 3
   Secadothe organic layer was dried over anh. Na2SO4
4. 4
   FiltraciónThe solids were filtered
5. 5
   Otrothe solvent evaporated

Procedimiento

To a solution of 6-bromo-2-pyridinamine (1 g, 5.78 mmol) in anh. THF (25 mL), at r.t., under N2, was added 1-chloro-2-isocyanatoethane (1.2 mL, 2.5 eq) and the reaction mixture was stirred at r.t. for 18 hr. The crude mixture was partitioned between CH2Cl2 and water. The phases were separated and the organic layer was dried over anh. Na2SO4. The solids were filtered and the solvent evaporated to give the title compound (1.06 g, 66%) which was used in the next step without further purification.

Fuente