Reacción #61070

Ecuación de reacción

water CH2Cl2

3-bromo-pyrazole

triphenylmethyl chloride

Et3N

→

title compound

Rendimiento 64.0%

3-Bromo-1-(triphenylmethyl)-1H-pyrazole

Rendimiento 64.0%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe phases were separated
2. 2
   Extracciónthe aqueous layer was further extracted with CH2Cl2 (2×30 mL)
3. 3
   SecadoThe combined organic extracts were dried over anh. Na2SO4
4. 4
   Filtraciónthe solids were filtered
5. 5
   Otrothe solvent evaporated
6. 6
   OtroThe residue was purified by flash chromatography (silica gel, 100% CH2Cl2)

Procedimiento

To a solution of 3-bromo-pyrazole (2.0 g, 13.6 mmol) in anh. CH2Cl2 (40 mL), at r.t., under N2, were added triphenylmethyl chloride (4.17 g, 1.1 eq) and Et3N (2.1 mL, 1.1 eq). The reaction mixture was stirred at r.t. for 4 hr. It was poured into water/CH2Cl2. The phases were separated and the aqueous layer was further extracted with CH2Cl2 (2×30 mL). The combined organic extracts were dried over anh. Na2SO4, the solids were filtered and the solvent evaporated. The residue was purified by flash chromatography (silica gel, 100% CH2Cl2) to give the title compound as a white solid (3.39 g, 64%).

Fuente