Reacción #61001

ord-b02c760935464a53870c03379f4ddb4d

Ecuación de reacción

CSc1ccc(N2CCOCC2)c(C(=O)O)c1
5-Methylsulfanyl-2-morpholin-4-yl-benzoic acid
CC(=O)c1ccc(N2CCNCC2)c(F)c1
1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone
→
CSc1ccc(N2CCOCC2)c(C(=O)N2CCN(c3ccc(C(C)=O)cc3F)CC2)c1
title compound
CSc1ccc(N2CCOCC2)c(C(=O)N2CCN(c3ccc(C(C)=O)cc3F)CC2)c1
1-{3-Fluoro-4-[4-(5-methylsulfanyl-2-morpholin-4-yl-benzoyl)-piperazin-1-yl]-phenyl}-ethanone

Reactantes

CSc1ccc(N2CCOCC2)c(C(=O)O)c1
5-Methylsulfanyl-2-morpholin-4-yl-benzoic acid
CC(=O)c1ccc(N2CCNCC2)c(F)c1
1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared according to the procedure described for example K step 2 from 5-Methylsulfanyl-2-morpholin-4-yl-benzoic acid and 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone (8%, white solid), MS (m/e): 458.2 (M+, 100%)

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07427612B2uspto-grants-2008_09