Reacción #60812

Ecuación de reacción

6-methyl-4-chlorofuro[2,3-d]pyrimidine

sodium thiomethoxide

→

title compound

Rendimiento 90.0%

6-Methyl-4-(methylthio)furo[2,3-d]pyrimidine

Rendimiento 90.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered
2. 2
   Lavadothe solids washed with acetonitrile
3. 3
   OtroEvaporation of the solvent

Procedimiento

A solution of 6-methyl-4-chlorofuro[2,3-d]pyrimidine (U.S. Pat. No. 3,577,420, example IG) (219 mg) in acetonitrile (25 mL) was heated under reflux with sodium thiomethoxide (190 mg) for 16 hours. The mixture was filtered and the solids washed with acetonitrile. Evaporation of the solvent afforded the title compound as a white solid (230 mg, 90%);

Fuente