Reacción #60810

Ecuación de reacción

sodium thiomethoxide

6-methyl-4-chlorothieno[3,2-d]pyrimidine

→

title compound

Rendimiento 97.0%

6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine

Rendimiento 97.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered
2. 2
   Lavadothe solid was washed with acetonitrile
3. 3
   OtroThe combined filtrate and washes were evaporated

Procedimiento

A solution of sodium thiomethoxide (24S mg) and 6-methyl-4-chlorothieno[3,2-d]pyrimidine (Acta Pol. Pharm. (1986), 43(2), 97-100) (650 mg) in acetonitrile (50 mL) was stirred overnight. The mixture was filtered and the solid was washed with acetonitrile. The combined filtrate and washes were evaporated to give the title compound as a white solid (665 mg, 97%);

Fuente