Reacción #60807

Ecuación de reacción

Sodium thiomethoxide

4-chlorothieno[3,2-d]pyrimidine

water

→

title compound

Rendimiento 69.0%

4-(Methylthio)thieno[3,2-d]pyrimidine

Rendimiento 69.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted into EtOAc
2. 2
   Lavadowashed with water
3. 3
   Secadodried (MgSO4)
4. 4
   Otrothe solvent removed
5. 5
   OtroPurification by flash chromatography on silica eluting with DCM:EtOAc (4:1)

Procedimiento

Sodium thiomethoxide (9.1 g) was added to a solution of 4-chlorothieno[3,2-d]pyrimidine (WO9849899, example 3A; WO9924440, example 1C) (17.0 g) in DMF (100 mL). After stirring for 90 minutes the mixture was poured into water (400 mL), extracted into EtOAc, washed with water, dried (MgSO4), and the solvent removed. Purification by flash chromatography on silica eluting with DCM:EtOAc (4:1) gave the title compound as a pale yellow solid (16.5 g, 69%);

Fuente