Reacción #607730

Ecuación de reacción

Methyl [(2R,6S)-2,6-dimethyl-4-morpholinyl]acetate

hydrazine hydrate

→

title compound

Rendimiento 66.3%

2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]acetohydrazide

Rendimiento 66.3%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe solvent was partially concentrated in vacuo
2. 2
   Otroto remove the methanol
3. 3
   Extracciónextracted with ethyl acetate (3×20 ml)
4. 4
   OtroThe combined organic layers were dried
5. 5
   Concentraciónconcentrated

Procedimiento

Methyl [(2R,6S)-2,6-dimethyl-4-morpholinyl]acetate (5.05 g, 27.0 mmol, see Journal of Fluorine Chemistry (1998) 193-201 for literature preparation) was dissolved in methanol (20 ml) and hydrazine hydrate (2.013 ml, 27.0 mmol) added. The reaction mixture was heated to 70° C. for 18 h. The solvent was partially concentrated in vacuo to remove the methanol and extracted with ethyl acetate (3×20 ml). The combined organic layers were dried and concentrated to afford the title compound as a yellow solid (3.35 g).

Fuente