Reacción #607493

Ecuación de reacción

4-bromo-2-fluorobenzoic acid

oxalyl chloride

DMF

→

4-bromo-2-fluorobenzoyl chloride

Rendimiento 100.1%

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture was concentrated under reduced pressure

Procedimiento

To a solution of 4-bromo-2-fluorobenzoic acid 144a (250 g, 1.14 mol) in dry DCM (2000 mL) was added oxalyl chloride (446 g, 3.51 mol) and DMF (10 mL) at RT, and the reaction mixture was stirred at RT for 1 h. See FIG. 3. The mixture was concentrated under reduced pressure to give 4-bromo-2-fluorobenzoyl chloride 144b (271 g, 100%) as a yellow solid, which was used for the next step without further purification.

Fuente