Reacción #607487

Ecuación de reacción

137g

3-(1,3-dioxoisoindolin-2-yl)propanoic acid

oxalyl chloride

DMF

→

3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride

Rendimiento 92.5%

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroUpon reaction completion
2. 2
   Concentraciónthe mixture was concentrated

Procedimiento

To a solution of 137g (20.0 g, 91 mmol) in DCM (250 mL) were added oxalyl chloride (13.8 g, 109 mmol) and DMF (0.1 mL). See FIG. 2. The mixture was stirred at RT for 4 h. Upon reaction completion, the mixture was concentrated to give 3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 137h (20.0 g, 92%) as a white solid.

Fuente