Reacción #607459

ord-93ad2b7e24c4493792906455e992d7bf

Ecuación de reacción

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
OCC(O)CO
glycerol
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Apomorphine

Reactantes

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
—
sodium carboxymethylcellulose
OCC(O)CO
glycerol

Reactivos

Ninguno

Disolventes

O
Water

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    workup.ADDITIONThe resulting mixture is mixed thoroughly (i.e.
  2. 2
    Otroto form a hydrogel
  3. 3
    workup.ADDITIONcontaining

Procedimiento

The particulate apomorphine is combined with sodium carboxymethylcellulose and glycerol. The resulting mixture is mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Water is added to the mixture (with extensive mixing) to form a hydrogel containing suspended nanoparticles of apomorphine hydrochloride.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09326981B2uspto-grants-2016_05