Reacción #606594
ord-b96bf9f8e80d4022b60557d95689ad66
Ecuación de reacción
Boc-L-Arg-OH
H-L-Trp-OBzl hydrochloride
HOBt
DIPEA
HBTU
→
yellowish solid
Rendimiento 123.5%
Boc-L-Arg-L-Trp-OBzl
Rendimiento 123.5%
Reactivos
Ninguno
Disolventes
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Tratamiento posterior
- 1OtroEvaporation
Procedimiento
To a stirred solution of Boc-L-Arg-OH (792 mg, 2.75 mmoles), H-L-Trp-OBzl hydrochloride (832 mg, 2.5 mmoles), HOBt (1378 mg, 9 mmoles) and DIPEA (2.05 ml, 12 mmoles) in DMF (6 ml) and dichloromethane (3 ml) cooled on ice was added HBTU (1138 mg, 3 mmoles) in small portions over 10 minutes. The mixture was stirred on ice for 45 minutes and at room temperature for 45 minutes. Workup was performed as described for KP-2-1. Evaporation afforded 1.7 g of a yellowish solid.