Reacción #60592

Ecuación de reacción

sodium carbonate

1-(2-fluorobenzyl)indazole-3-amidinium chloride

sodium hydroxide

→

1-(2-Fluorobenzyl)-3-cyanoindazole

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrohave separated
2. 2
   LavadoThe organic phase is washed with saturated sodium chloride solution
3. 3
   Secadodried over magnesium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Otrothe solvent is removed in vacuo
6. 6
   Otro3.33 g (76% of theory) of the product are obtained

Procedimiento

2.61 g (24.61 mmol) of sodium carbonate as 10% strength aqueous solution are added to a suspension of 5.00 g (16.41 mmol) of 1-(2-fluorobenzyl)indazole-3-amidinium chloride from Example IIIb) in 100 ml of ethyl acetate, and the mixture is stirred at room temperature for 90 minutes. One molar sodium hydroxide solution is added until the phases have separated. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulfate and filtered, and the solvent is removed in vacuo. 3.33 g (76% of theory) of the product are obtained.

Fuente